Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2738-42. doi: 10.1002/anie.201510269. Epub 2016 Jan 25.


The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K(+) ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization.

Keywords: DNA structures; G-quadruplexes; IR spectroscopy; NMR spectroscopy; azobenzene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • G-Quadruplexes*
  • Models, Molecular
  • Nucleic Acid Conformation
  • Photochemistry
  • Proton Magnetic Resonance Spectroscopy