Rediscovering area CA2: unique properties and functions

Nat Rev Neurosci. 2016 Feb;17(2):89-102. doi: 10.1038/nrn.2015.22.


Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cell death. A recent increase in interest in the CA2 region, combined with the development of new methods to define and manipulate its neurons, has led to some exciting new discoveries on the properties of CA2 neurons and their role in behaviour. Here, we review these findings and call attention to the idea that the definition of area CA2 ought to be revised in light of gene expression data.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • CA2 Region, Hippocampal / cytology
  • CA2 Region, Hippocampal / physiology*
  • Humans
  • Learning / physiology*
  • Nerve Net / physiology
  • Neuronal Plasticity / physiology*
  • Neurons / physiology
  • Social Behavior*