Long non-coding RNA derived miR-205-5p modulates human endometrial cancer by targeting PTEN

Weijuan Xin; Xiaoxia Liu; Jingxin Ding; Jing Zhao; Yang Zhou; Qianyu Wu; Keqin Hua

Long non-coding RNA derived miR-205-5p modulates human endometrial cancer by targeting PTEN

Am J Transl Res. 2015 Nov 15;7(11):2433-41. eCollection 2015.

Authors

Weijuan Xin¹, Xiaoxia Liu¹, Jingxin Ding¹, Jing Zhao¹, Yang Zhou², Qianyu Wu³, Keqin Hua¹

Affiliations

¹ Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University Shanghai 200032, China.
² Department of Regenerative Medicine, Tongji University School of Medicine Shanghai 200092, China.
³ Department of Obstetrics and Gynecology, East Hospital of Tongji University Shanghai 200120, China.

PMID: 26807189
PMCID: PMC4697721

Abstract

Objective: This study was to investigate the roles of lncRNA associated competitive endogenous RNAs (ceRNAs) network in the endometrial cancer (EC).

Methods: StarbaseV2.0 online software was used to predict the most probable lncRNAs which contain miR-205-5p binding site and are competent to interact with miR-205-5p. Then, lncRNAs which had decreased expression in EC compared with normal endometrium and conformed to the polyadenylated characteristics of lncRNAs were selected and then lncRNAs associated with miR-205-5p-PTEN network were identified.

Results: Two novel genes RP11-395G23.3 and LA16c-313D11.11 associated with endometrial cancer were identified and proved to be non-coding RNAs. They were more effective ceRNAs associated with the miR-205-5p-PTEN network.

Conclusion: Our results suggest that lncRNAs harbor MREs (miRNA response elements) and play important roles in the post-transcriptional regulation in EC.

Keywords: endometrial cancer; lncRNA; miR-205-5p; phosphatase and tensin homolog deleted on chromosome ten.