Combinatorial synthesis of deuterium-enriched atorvastatin

Feng Li; Wenfeng Jiang; Anthony W Czarnik; Wenbao Li

doi:10.1007/s11030-015-9655-6

Combinatorial synthesis of deuterium-enriched atorvastatin

Mol Divers. 2016 May;20(2):453-9. doi: 10.1007/s11030-015-9655-6. Epub 2016 Jan 25.

Authors

Feng Li^{1

2}, Wenfeng Jiang^{1

2}, Anthony W Czarnik³, Wenbao Li^{4

5}

Affiliations

¹ School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
² Marine Biomedical Research Institute, Qingdao, 266071, China.
³ Department of Chemistry, University of Nevada, Reno, Reno, 89557-0216, USA. aczarnik@unr.edu.
⁴ School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. wbli92128@ouc.edu.cn.
⁵ Marine Biomedical Research Institute, Qingdao, 266071, China. wbli92128@ouc.edu.cn.

PMID: 26809618
DOI: 10.1007/s11030-015-9655-6

Abstract

It becomes more and more difficult to discover a new drug by existing models. The concept of deuteration has gained attention due to its advantages in the study of clinical pharmacokinetics and metabolic profiles. Herein we built a library of deuterated atorvastatins using combinatorial chemistry, and all 16 D-compounds were characterized by 1H NMR, 13C NMR, MS, and elemental analysis.

Keywords: Atorvastatin; Combinatorial chemistry; Deuterated derivatives; Deuterium.

MeSH terms

Atorvastatin / chemical synthesis*
Atorvastatin / chemistry*
Chemistry Techniques, Synthetic
Combinatorial Chemistry Techniques
Deuterium / chemistry*

Substances

Atorvastatin
Deuterium