Gene Regulation: Stable Noise

Jonathan R Chubb

doi:10.1016/j.cub.2015.12.002

Gene Regulation: Stable Noise

Curr Biol. 2016 Jan 25;26(2):R61-R64. doi: 10.1016/j.cub.2015.12.002.

Author

Jonathan R Chubb¹

Affiliation

¹ MRC Laboratory for Molecular Cell Biology and Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: j.chubb@ucl.ac.uk.

PMID: 26811888
DOI: 10.1016/j.cub.2015.12.002

Abstract

Transcriptional regulation is noisy, yet despite this variability, embryonic development reproducibly generates form and function. Recent work demonstrates that patterns of transcriptional activity in embryos are stably inherited through mitosis. These observations have implications for how accuracy arises in development.

Publication types

Comment

MeSH terms

Embryonic Development / genetics
Gene Expression Regulation*
Gene Expression Regulation, Developmental
Noise*
Proteins / metabolism
Transcriptional Activation

Substances

Proteins

Grants and funding

090904/Wellcome Trust/United Kingdom