Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone

J Clin Endocrinol Metab. 2016 Apr;101(4):1469-77. doi: 10.1210/jc.2015-3694. Epub 2016 Jan 26.

Abstract

In this study we tested the use of salivary cortisol and cortisone as alternatives to serum cortisol. Salivary cortisol is often undetectable and contaminated by hydrocortisone. Salivary cortisone strongly reflects serum cortisol.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Chromatography, Liquid
  • Circadian Rhythm
  • Cortisone / analysis*
  • Cross-Over Studies
  • Humans
  • Hydrocortisone / metabolism*
  • Male
  • Prospective Studies
  • Saliva / chemistry*
  • Salivary Glands / metabolism*
  • Salivary Glands / pathology
  • Tandem Mass Spectrometry

Substances

  • Cortisone
  • Hydrocortisone