Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance

J Pediatr. 2016 Apr;171:90-6.e1. doi: 10.1016/j.jpeds.2015.12.061. Epub 2016 Jan 23.


Objective: To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents.

Study design: Adolescents (n = 1454, aged 12-16 years) were assessed in a study conducted to monitor Multilevel Risk Profiles for Adolescent Metabolic Syndrome in Taiwan. Detailed information about demographics, diet, physical, anthropometric, and clinical variables was collected. An original homeostatic model assessment of IR (HOMA1-IR), updated nonlinear homeostatic model assessment of IR (HOMA2-IR) model, and several IR markers were measured.

Results: Adolescents who consumed a greater amount of SSBs were more likely to have elevated fasting serum insulin, HOMA1-IR, and HOMA2-IR (P for trends, ≤.028). Compared with SSB nondrinkers, those with >350 mL/d intake of heavy high-fructose corn syrup-containing SSBs had a 0.52 and 0.30 higher multivariate-adjusted HOMA1-IR and HOMA2-IR, respectively. Waist circumference and serum uric acid were correspondingly found to explain 25.4% and 23.6%, as well as 23.2% and 20.6%, of the increases in the 2 IR markers. Both the elevations of HOMA1-IR and HOMA2-IR for high-fructose corn syrup-rich SSB intake were strengthened among obese adolescents (P for interaction, ≤.033).

Conclusions: Fructose-rich SSB intake is associated with elevated levels of IR, and this relationship may be partially mediated by central adiposity and serum uric acid. Obesity may modify the effect of this type of SSB consumption in intensifying the elevation of IR in adolescents.

Publication types

  • Clinical Trial, Phase II
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anthropometry
  • Beverages*
  • Biomarkers / blood
  • Child
  • Cross-Sectional Studies
  • Feeding Behavior
  • Female
  • Fructose / adverse effects*
  • Homeostasis
  • Humans
  • Insulin Resistance*
  • Male
  • Motor Activity
  • Multivariate Analysis
  • Obesity, Abdominal / blood
  • Obesity, Abdominal / physiopathology*
  • Pediatric Obesity / blood
  • Pediatric Obesity / physiopathology
  • Surveys and Questionnaires
  • Taiwan
  • Uric Acid / blood*
  • Waist Circumference


  • Biomarkers
  • Uric Acid
  • Fructose