How May Proton Pump Inhibitors Impair Cardiovascular Health?

Am J Cardiovasc Drugs. 2016 Jun;16(3):153-61. doi: 10.1007/s40256-016-0160-9.


Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an increased cardiovascular risk. In this article, we review the clinical evidence for adverse cardiovascular effects of PPIs, and we discuss possible biological mechanisms by which PPIs can impair cardiovascular health.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Ulcer Agents / adverse effects
  • Cardiovascular Diseases / chemically induced*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular System / drug effects*
  • Cardiovascular System / metabolism
  • Cardiovascular System / physiopathology
  • Drug Monitoring
  • Evidence-Based Medicine*
  • Humans
  • Models, Cardiovascular*
  • Nonprescription Drugs / adverse effects
  • Practice Guidelines as Topic
  • Proton Pump Inhibitors / adverse effects*
  • Risk Factors


  • Anti-Ulcer Agents
  • Nonprescription Drugs
  • Proton Pump Inhibitors