Diagnostic Performance of Xpert MTB/RIF in Tuberculous Pleural Effusion: Systematic Review and Meta-analysis

Inderpaul Singh Sehgal; Sahajal Dhooria; Ashutosh Nath Aggarwal; Digambar Behera; Ritesh Agarwal

doi:10.1128/JCM.03205-15

Diagnostic Performance of Xpert MTB/RIF in Tuberculous Pleural Effusion: Systematic Review and Meta-analysis

J Clin Microbiol. 2016 Apr;54(4):1133-6. doi: 10.1128/JCM.03205-15. Epub 2016 Jan 27.

Authors

Inderpaul Singh Sehgal¹, Sahajal Dhooria¹, Ashutosh Nath Aggarwal¹, Digambar Behera¹, Ritesh Agarwal²

Affiliations

¹ Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
² Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India agarwal.ritesh@outlook.in.

Abstract

A systematic review investigating the role of Xpert MTB/RIF in the diagnosis of tuberculous pleural effusion (TPE) was conducted. The pooled sensitivities and specificities of Xpert MTB/RIF were 51.4% and 98.6%, respectively, with culture used as a reference standard and 22.7% and 99.8%, respectively, with a composite reference standard (CRS) used as the benchmark. Xpert MTB/RIF has low sensitivity but excellent specificity in the diagnosis of TPE.

Publication types

Evaluation Study
Meta-Analysis
Review
Systematic Review

MeSH terms

Antitubercular Agents / pharmacology*
Drug Resistance, Bacterial*
Humans
Molecular Diagnostic Techniques / methods*
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / isolation & purification*
Pleural Effusion / microbiology*
Rifampin / pharmacology*
Sensitivity and Specificity
Tuberculosis, Multidrug-Resistant / diagnosis
Tuberculosis, Pleural / diagnosis*

Substances

Antitubercular Agents
Rifampin

Grants and funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.