German guidelines for the diagnosis and therapy of localized scleroderma

J Dtsch Dermatol Ges. 2016 Feb;14(2):199-216. doi: 10.1111/ddg.12724.


Localized scleroderma designates a heterogeneous group of sclerotic skin disorders. Depending on the subtype, severity, and site affected, adjacent structures such as adipose tissue, muscles, joints, and bones may be involved. This is an update of the existing German AWMF (Association of the Scientific Medical Societies in Germany) guidelines (classification: S2k). These guidelines provide an overview of the definition, epidemiology, classification, pathogenesis, laboratory workup, histopathology, clinical scoring systems, as well as imaging and device-based workup of localized scleroderma. Moreover, consensus-based recommendations are given on the management of localized scleroderma depending on its clinical subtype. Treatment recommendations are presented in a therapeutic algorithm. No financial support was given by any pharmaceutical company. The guidelines are valid until July 2019.

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Dermatologic Agents / therapeutic use
  • Dermatology / standards*
  • Dermoscopy / standards*
  • Germany
  • Humans
  • Magnetic Resonance Imaging / standards*
  • Practice Guidelines as Topic*
  • Scleroderma, Localized / diagnosis*
  • Scleroderma, Localized / therapy*


  • Anti-Inflammatory Agents
  • Dermatologic Agents