Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis

Mediators Inflamm. 2015:2015:642503. doi: 10.1155/2015/642503. Epub 2015 Dec 27.


Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent clinical and functional cross-sectional evaluation, including microbiologic and inflammatory cell profile in sputum, and exhaled breath condensate malondialdehyde (EBC-MDA). NFCB severity was assessed using BSI and FACED criteria. Results. Sputum neutrophil percentages inversely correlated with FEV1 (P < 0.0001; rho = -0.428), weakly with Leicester Cough Questionnaire score (P = 0.068; rho = -0.58), and directly with duration of the disease (P = 0.004; rho = 0.3) and BSI severity score (P = 0.005; rho = 0.37), but not with FACED. Sputum neutrophilia was higher in colonized subjects, P. aeruginosa colonized subjects showing greater sputum neutrophilia and lower FEV1. Patients with ≥3 exacerbations in the last year showed a significantly greater EBC-MDA than the remaining patients. Conclusions. Sputum neutrophilic inflammation and biomarkers of oxidative stress in EBC can be considered good biomarkers of disease severity in NCFB patients, as confirmed by pulmonary function, disease duration, bacterial colonization, BSI score, and exacerbation rate.

MeSH terms

  • Adult
  • Aged
  • Breath Tests
  • Bronchi / pathology*
  • Bronchiectasis / drug therapy
  • Bronchiectasis / immunology*
  • Bronchiectasis / physiopathology
  • Cross-Sectional Studies
  • Female
  • Forced Expiratory Volume
  • Humans
  • Inflammation / physiopathology*
  • Male
  • Middle Aged
  • Neutrophils / physiology*
  • Oxidative Stress
  • Severity of Illness Index
  • Sputum / cytology*
  • Sputum / microbiology