Host restriction factors for hepatitis C virus

World J Gastroenterol. 2016 Jan 28;22(4):1477-86. doi: 10.3748/wjg.v22.i4.1477.


Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.

Keywords: Entry; Hepatitis C virus; Host restriction factor; Interferon; Propagation; Replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Hepacivirus / growth & development
  • Hepacivirus / metabolism
  • Hepacivirus / pathogenicity*
  • Hepatitis C / metabolism
  • Hepatitis C / virology*
  • Host-Pathogen Interactions
  • Humans
  • Signal Transduction
  • Virus Internalization
  • Virus Replication