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Clinical Features of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Other Connective Tissue Diseases


Clinical Features of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Other Connective Tissue Diseases

Tsuyoshi Kasama et al. Clin Med Insights Arthritis Musculoskelet Disord.


Systemic lupus erythematosus (SLE) and related disorders are chronic inflammatory diseases characterized by abnormalities and, in some cases, even complete failure of immune responses as the underlying pathology. Although almost all connective tissue diseases and related disorders can be complicated by various neuropsychiatric syndromes, SLE is a typical connective tissue disease that can cause neurological and psychiatric syndromes. In this review, neuropsychiatric syndromes complicating connective tissue diseases, especially SLE are outlined, and pathological and other conditions that should be considered in the differential diagnosis are also discussed.

Keywords: NPSLE; SLE; connective tissue diseases; neuropsychiatric syndromes.


Figure 1
Figure 1
Schematic overview of the development of NPSLE. Either ischemia or activation/depression of neuronal cells may be a crucial component for NPSLE. The direct and indirect effects of several cytokines and chemokines on the CNS have been emphasized as possible contributors. Notes: These autoantibodies include antineuronal antibodies, antiribosomal P antibodies, antineurofilament antibodies, and anti-NR2 antibodies. Abbreviation: APS, antiphospholipid antibody syndrome.

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