Ramping up degradation for proliferation

Nat Cell Biol. 2016 Feb;18(2):141-2. doi: 10.1038/ncb3306.


The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / enzymology*
  • Cell Proliferation*
  • Cell Transformation, Neoplastic / metabolism*
  • Female
  • Humans
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Protein-Tyrosine Kinases / metabolism*


  • Protein-Tyrosine Kinases
  • Protein Serine-Threonine Kinases
  • Proteasome Endopeptidase Complex