Chemotaxis During Neural Crest Migration

Semin Cell Dev Biol. 2016 Jul;55:111-8. doi: 10.1016/j.semcdb.2016.01.031. Epub 2016 Jan 25.

Abstract

Chemotaxis refers to the directional migration of cells towards external, soluble factors along their gradients. It is a process that is used by many different cell types during development for tissue organisation and the formation of embryonic structures, as well as disease like cancer metastasis. The neural crest (NC) is a multipotent, highly migratory cell population that contribute to a range of tissues. It has been hypothesised that NC migration, at least in part, is reliant on chemotactic signals. This review will explore the current evidence for proposed chemoattractants of NC cells, and outline mechanisms for the chemotactic response of the NC to them.

Keywords: C3/C3aR; Chemotaxis; Collective migration; Neural crest; SDF1/CXCL12; VEGF.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemotactic Factors / pharmacology
  • Chemotaxis* / drug effects
  • Humans
  • Models, Biological
  • Neural Crest / cytology*
  • Neural Crest / drug effects

Substances

  • Chemotactic Factors