Abstract
Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades.
Keywords:
marine alkaloids; pyridoacridines; total synthesis.
MeSH terms
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Acridines / isolation & purification
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Acridines / pharmacology*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Aquatic Organisms / metabolism*
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Drug Design
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Drug Discovery / methods
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Humans
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Phenanthrolines / isolation & purification
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Phenanthrolines / pharmacology*
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Secondary Metabolism
Substances
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Acridines
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Alkaloids
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Anti-Infective Agents
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Antineoplastic Agents
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Biological Products
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Phenanthrolines
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pyridoacridine