Secondary Use of Clinical Data to Enable Data-Driven Translational Science with Trustworthy Access Management

Mo Med. 2015 Nov-Dec;112(6):443-8.


University of Missouri (MU) Health Care produces a large amount of digitized clinical data that can be used in clinical and translational research for cohort identification, retrospective data analysis, feasibility study, and hypothesis generation. In this article, the implementation of an integrated clinical research data repository is discussed. We developed trustworthy access-management protocol for providing access to both clinically relevant data and protected health information. As of September 2014, the database contains approximately 400,000 patients and 82 million observations; and is growing daily. The system will facilitate the secondary use of electronic health record (EHR) data at MU to promote data-driven clinical and translational research, in turn enabling better healthcare through research.

MeSH terms

  • Academic Medical Centers / organization & administration*
  • Databases as Topic / organization & administration*
  • Electronic Health Records / organization & administration*
  • Humans
  • Medical Informatics / methods*
  • Missouri
  • Translational Research, Biomedical / methods*