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Review
. 2016;224:203-23.
doi: 10.1016/bs.pbr.2015.07.026. Epub 2015 Nov 4.

Genetic Imaging Consortium for Addiction Medicine: From Neuroimaging to Genes

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Free PMC article
Review

Genetic Imaging Consortium for Addiction Medicine: From Neuroimaging to Genes

Scott Mackey et al. Prog Brain Res. .
Free PMC article

Abstract

Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction. The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.

Keywords: Addiction; ENIGMA; Genetic imaging; Neuroimaging.

Figures

Figure 1
Figure 1
Illustration of a structural MRI brain scan processed with FreeSurfer. Left, example of automated parcellation of the cortex. Right, local cortical thickness projected onto inflated surface of the brain.
Figure 2
Figure 2
World map of the current membership of the ENIGMA Addiction working group.

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