The kinome 'at large' in cancer

Nat Rev Cancer. 2016 Feb;16(2):83-98. doi: 10.1038/nrc.2015.18.

Abstract

Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome 'at large' in human cancers, providing crucial insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer and how kinome remodelling modulates sensitivity to anticancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this Analysis article.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • High-Throughput Screening Assays
  • Histone Acetyltransferases / genetics
  • Histone Acetyltransferases / metabolism
  • Humans
  • Molecular Targeted Therapy / methods
  • Mutation
  • NIMA-Related Kinases
  • Neoplasms / enzymology*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Protein Kinases / genetics*
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Proteomics / methods
  • TATA-Binding Protein Associated Factors / genetics
  • TATA-Binding Protein Associated Factors / metabolism
  • Transcription Factor TFIID / genetics
  • Transcription Factor TFIID / metabolism

Substances

  • TATA-Binding Protein Associated Factors
  • Transcription Factor TFIID
  • Histone Acetyltransferases
  • Protein Kinases
  • NEK9 protein, human
  • NIMA-Related Kinases
  • Protein-Serine-Threonine Kinases
  • TATA-binding protein associated factor 250 kDa