Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

Nature. 1989 Nov 16;342(6247):238-43. doi: 10.1038/342238a0.


Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / genetics*
  • Chromosomes, Human, Pair 11*
  • Ethnicity
  • Genes, ras
  • Genetic Linkage
  • Genotype
  • Humans
  • Insulin / genetics
  • Pedigree
  • Pennsylvania


  • Insulin