BMP signaling in vascular biology and dysfunction

Cytokine Growth Factor Rev. 2016 Feb;27:65-79. doi: 10.1016/j.cytogfr.2015.12.005. Epub 2015 Dec 15.

Abstract

The vascular system is critical for developmental growth, tissue homeostasis and repair but also for tumor development. Bone morphogenetic protein (BMP) signaling has recently emerged as a fundamental pathway of the endothelium by regulating cardiovascular and lymphatic development and by being causative for several vascular dysfunctions. Two vascular disorders have been directly linked to impaired BMP signaling: pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia. Endothelial BMP signaling critically depends on the cellular context, which includes among others vascular heterogeneity, exposure to flow, and the intertwining with other signaling cascades (Notch, WNT, Hippo and hypoxia). The purpose of this review is to highlight the most recent findings illustrating the clear need for reconsidering the role of BMPs in vascular biology.

Keywords: Bone morphogenetic proteins (BMP); Development; Disease; Signaling; Vasculature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism*
  • Endothelium, Lymphatic / metabolism*
  • Endothelium, Vascular / metabolism*
  • Humans
  • Hypertension / genetics
  • Hypertension / metabolism
  • Signal Transduction*
  • Telangiectasia, Hereditary Hemorrhagic / genetics
  • Telangiectasia, Hereditary Hemorrhagic / metabolism*

Substances

  • Bone Morphogenetic Proteins