Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity

Martina Gast; Blanche Schroen; Antje Voigt; Jan Haas; Uwe Kuehl; Dirk Lassner; Carsten Skurk; Felicitas Escher; Xiaomin Wang; Adelheid Kratzer; Katharina Michalik; Anna Papageorgiou; Tim Peters; Madlen Loebel; Sabrina Wilk; Nadine Althof; Kannanganattu V Prasanth; Hugo Katus; Benjamin Meder; Shinichi Nakagawa; Carmen Scheibenbogen; Heinz-Peter Schultheiss; Ulf Landmesser; Stefanie Dimmeler; Stephane Heymans; Wolfgang Poller

doi:10.1093/jmcb/mjw003

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity

J Mol Cell Biol. 2016 Apr;8(2):178-81. doi: 10.1093/jmcb/mjw003. Epub 2016 Jan 27.

Authors

Martina Gast¹, Blanche Schroen², Antje Voigt³, Jan Haas⁴, Uwe Kuehl⁵, Dirk Lassner⁶, Carsten Skurk¹, Felicitas Escher⁵, Xiaomin Wang¹, Adelheid Kratzer¹, Katharina Michalik⁷, Anna Papageorgiou², Tim Peters², Madlen Loebel⁸, Sabrina Wilk⁹, Nadine Althof³, Kannanganattu V Prasanth¹⁰, Hugo Katus⁴, Benjamin Meder⁴, Shinichi Nakagawa¹¹, Carmen Scheibenbogen⁸, Heinz-Peter Schultheiss¹, Ulf Landmesser¹², Stefanie Dimmeler¹³, Stephane Heymans², Wolfgang Poller¹⁴

Affiliations

¹ Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
² Center for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.
³ Institute of Biochemistry, Campus Charite Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁴ Otto-Meyerhof-Centrum, University of Heidelberg, Heidelberg, Germany Medizinische Klinik, University of Heidelberg, Heidelberg, Germany.
⁵ Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany.
⁶ Institute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany.
⁷ Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt, Germany.
⁸ Institute for Medical Immunology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany Berlin Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁹ Institute for Medical Immunology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹⁰ Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
¹¹ RNA Biology Laboratory, RIKEN Advanced Research Institute, Wako, Saitama 351-0198, Japan.
¹² Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany German Center for Cardiovascular Research (DZHK), Site Berlin, Germany.
¹³ Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt, Germany DZHK, Site Rhein-Main, Germany.
¹⁴ Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany Berlin Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany German Center for Cardiovascular Research (DZHK), Site Berlin, Germany wolfgang.poller@charite.de.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cardiovascular System / immunology*
Cardiovascular System / metabolism*
Humans
Immunity, Innate / genetics*
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism*

Substances

MALAT1 long non-coding RNA, human
RNA, Long Noncoding

Grants and funding

R01 GM088252/GM/NIGMS NIH HHS/United States