Survey of Carbapenemase-Producing Enterobacteriaceae in Companion Dogs in Madrid, Spain

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2499-501. doi: 10.1128/AAC.02383-15. Print 2016 Apr.

Abstract

We found a low prevalence (0.6%) of carbapenemase-producingEnterobacteriaceae(CPE) in fecal microbiota of companion dogs. A single VIM-1-producingKlebsiella pneumoniaeisolate belonging to sequence type (ST) 2090 was detected.blaVIM-1was carried on a class 1 integron and an untypeable ∼48-kb plasmid. Emergence and spread of CPE in this group of animals may be a threat to public health in human and veterinary medicine. This finding supports the need for active surveillance studies in companion animals that live close to humans, as interspecies transmission may occur within the same household.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Carbapenems / pharmacology*
  • Dogs
  • Epidemiological Monitoring
  • Feces / microbiology
  • Gene Expression
  • Humans
  • Integrons
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / microbiology
  • Klebsiella Infections / transmission
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / growth & development
  • Pets
  • Plasmids / chemistry
  • Plasmids / metabolism*
  • Prevalence
  • Spain / epidemiology
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • VIM-1 metallo-beta-lactamase
  • beta-Lactamases