Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies

Planta Med. 1989 Oct;55(5):423-8. doi: 10.1055/s-2006-962057.


Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased the hepatic glucose-6-phosphate and glycogen synthetase activities and did not affect the activities of hexokinase and glycogen phosphorylase. Ganoderan B reduced the glycogen content in the liver but had no influence on total cholesterol and triglyceride levels in the plasma and liver.

MeSH terms

  • Animals
  • Cholesterol / metabolism
  • Glucose / metabolism
  • Insulin / blood*
  • Liver / enzymology
  • Male
  • Mice
  • Polysaccharides / pharmacology*
  • Triglycerides / metabolism


  • Insulin
  • Polysaccharides
  • Triglycerides
  • Cholesterol
  • ganoderan B
  • Glucose