Reduced germinal center follicular helper T cells but normal follicular regulatory T cells in the tonsils of a patient with a mutation in the PI3KR1 gene

Clin Immunol. 2016 Mar:164:43-4. doi: 10.1016/j.clim.2016.01.016. Epub 2016 Jan 28.

Authors

Roberta Di Fonte¹, Manuela Baronio², Alessandro Plebani², Vassilios Lougaris², Georgia Fousteri³

Affiliations

¹ Diabetes Research Institute, San Raffaele Hospital IRCCS, Milan, Italy.
² Pediatrics Clinic, Institute for Molecular Medicine A. Novicelli, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
³ Diabetes Research Institute, San Raffaele Hospital IRCCS, Milan, Italy. Electronic address: fousteri.georgia@hsr.it.

PMID: 26827886
DOI: 10.1016/j.clim.2016.01.016

No abstract available

Keywords: Germinal Centers; Hyper-IgM syndrome; PI3KR1; T follicular helper cells; T follicular regulatory cells; Tonsil.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Class Ia Phosphatidylinositol 3-Kinase
Germinal Center / immunology*
Humans
Mutation
Palatine Tonsil / immunology*
Phosphatidylinositol 3-Kinases / genetics*
Phosphatidylinositol 3-Kinases / immunology*
T-Lymphocytes, Helper-Inducer / immunology*
T-Lymphocytes, Regulatory / immunology

Substances

PIK3R1 protein, human
Class Ia Phosphatidylinositol 3-Kinase