Engineering broadly neutralizing antibodies for HIV prevention and therapy

Adv Drug Deliv Rev. 2016 Aug 1;103:157-173. doi: 10.1016/j.addr.2016.01.013. Epub 2016 Jan 29.

Abstract

A combination of advances spanning from isolation to delivery of potent HIV-specific antibodies has begun to revolutionize understandings of antibody-mediated antiviral activity. As a result, the set of broadly neutralizing and highly protective antibodies has grown in number, diversity, potency, and breadth of viral recognition and neutralization. These antibodies are now being further enhanced by rational engineering of their anti-HIV activities and coupled to cutting edge gene delivery and strategies to optimize their pharmacokinetics and biodistribution. As a result, the prospects for clinical use of HIV-specific antibodies to treat, clear, and prevent HIV infection are gaining momentum. Here we discuss the diverse methods whereby antibodies are being optimized for neutralization potency and breadth, biodistribution, pharmacokinetics, and effector function with the aim of revolutionizing HIV treatment and prevention options.

Keywords: Antibody; Effector function; HIV; Neutralization; Prevention; Therapy.

Publication types

  • Review

MeSH terms

  • Antibodies, Neutralizing / immunology
  • Antibodies, Neutralizing / therapeutic use*
  • HIV Antibodies / immunology
  • HIV Antibodies / therapeutic use*
  • HIV Infections* / prevention & control
  • HIV Infections* / therapy
  • HIV-1 / immunology*
  • Humans

Substances

  • Antibodies, Neutralizing
  • HIV Antibodies