Abstract
Wortmannolol (1), a new furanosteroid, along with five known compounds, wortmannolone (2), ergosterol (3), p-hydroxyphenyl ethanol (4), trans-6-dodecene (5), (2Z, 4E) -5-(8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo [3.2.1] octan-8-yl) -3-methylpenta-2,4-dienoic acid (6) were isolated from a fungal endophyte Talaromyces sp. lgt-4. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. Compound 1 show weak monoamine oxidase inhibitory activity.
Keywords:
Furanosteroid; Talaromyces; Tripterygium wilfordii; endophyte.
MeSH terms
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Alkanes / isolation & purification
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Alkanes / pharmacology
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Drug Evaluation, Preclinical / methods
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Endophytes / chemistry
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Ergosterol / isolation & purification
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Ergosterol / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Monoamine Oxidase Inhibitors / chemistry
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Monoamine Oxidase Inhibitors / pharmacology
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Phenylethyl Alcohol / analogs & derivatives
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Phenylethyl Alcohol / isolation & purification
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Phenylethyl Alcohol / pharmacology
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Sterols / isolation & purification
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Sterols / pharmacology
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Talaromyces / chemistry*
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Tripterygium / microbiology
Substances
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Alkanes
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Monoamine Oxidase Inhibitors
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Sterols
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wortmannolol
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4-hydroxyphenylethanol
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Phenylethyl Alcohol
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Ergosterol