A new furanosteroid from Talaromyces sp. lgt-4, a fungal endophyte isolated from Tripterygium wilfordii

Nat Prod Res. 2016 Oct;30(19):2137-41. doi: 10.1080/14786419.2016.1138301. Epub 2016 Feb 1.

Abstract

Wortmannolol (1), a new furanosteroid, along with five known compounds, wortmannolone (2), ergosterol (3), p-hydroxyphenyl ethanol (4), trans-6-dodecene (5), (2Z, 4E) -5-(8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo [3.2.1] octan-8-yl) -3-methylpenta-2,4-dienoic acid (6) were isolated from a fungal endophyte Talaromyces sp. lgt-4. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. Compound 1 show weak monoamine oxidase inhibitory activity.

Keywords: Furanosteroid; Talaromyces; Tripterygium wilfordii; endophyte.

MeSH terms

  • Alkanes / isolation & purification
  • Alkanes / pharmacology
  • Drug Evaluation, Preclinical / methods
  • Endophytes / chemistry
  • Ergosterol / isolation & purification
  • Ergosterol / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Monoamine Oxidase Inhibitors / chemistry
  • Monoamine Oxidase Inhibitors / pharmacology
  • Phenylethyl Alcohol / analogs & derivatives
  • Phenylethyl Alcohol / isolation & purification
  • Phenylethyl Alcohol / pharmacology
  • Sterols / isolation & purification
  • Sterols / pharmacology
  • Talaromyces / chemistry*
  • Tripterygium / microbiology

Substances

  • Alkanes
  • Monoamine Oxidase Inhibitors
  • Sterols
  • wortmannolol
  • 4-hydroxyphenylethanol
  • Phenylethyl Alcohol
  • Ergosterol