Combination chemoprevention with grape antioxidants

Mol Nutr Food Res. 2016 Jun;60(6):1406-15. doi: 10.1002/mnfr.201500945. Epub 2016 Mar 3.


Antioxidant ingredients present in grape have been extensively investigated for their cancer chemopreventive effects. However, much of the work has been done on individual ingredients, especially focusing on resveratrol and quercetin. Phytochemically, whole grape represents a combination of numerous phytonutrients. Limited research has been done on the possible synergistic/additive/antagonistic interactions among the grape constituents. Among these phytochemical constituents of grapes, resveratrol, quercetin, kaempferol, catechin, epicatechin, and anthocyanins (cyanidin and malvidin) constitute more than 70% of the grape polyphenols. Therefore, these have been relatively well studied for their chemopreventive effects against a variety of cancers. While a wealth of information is available individually on cancer chemopreventive/anti-proliferative effects of resveratrol and quercetin, limited information is available regarding the other major constituents of grape. Studies have also suggested that multiple grape antioxidants, when used in combination, alone or with other agents/drugs show synergistic or additive anti-proliferative response. Based on strong rationale emanating from published studies, it seems probable that a combination of multiple grape ingredients alone or together with other agents could impart 'additive synergism' against cancer.

Keywords: Anthocyanin; Combination chemoprevention; Epicatechin; Grape antioxidants; Resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthocyanins / pharmacology
  • Anticarcinogenic Agents / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology
  • Antioxidants / pharmacology*
  • Catechin / pharmacology
  • Cell Line, Tumor
  • Chemoprevention*
  • Disease Models, Animal
  • Humans
  • Kaempferols / pharmacology
  • Neoplasms / drug therapy
  • Neoplasms / prevention & control*
  • Plant Extracts / pharmacology*
  • Polyphenols / pharmacology
  • Quercetin / pharmacology
  • Resveratrol
  • Stilbenes / pharmacology
  • Vitis / chemistry*


  • Anthocyanins
  • Anticarcinogenic Agents
  • Antioxidants
  • Kaempferols
  • Plant Extracts
  • Polyphenols
  • Stilbenes
  • malvidin
  • kaempferol
  • cyanidin
  • Catechin
  • Quercetin
  • Resveratrol