Positive effects of egg-derived phospholipids in patients with metabolic syndrome

Adv Med Sci. 2016 Mar;61(1):169-74. doi: 10.1016/j.advms.2015.12.003. Epub 2016 Jan 13.


Purpose: Patients with metabolic syndrome (MBS) have an increased risk of all-cause mortality, especially from cardiovascular disease. Egg phospholipids (PL) have been shown to exert a positive impact on cholesterol metabolism and inflammation; eggs are an important source of PL. Our study examined potential effects of egg-yolk-derived PL in non-diabetic patients with MBS.

Methods: The study group consisted of 40 patients with MBS diagnosed according to IDF criteria and divided into an experimental group receiving the PL preparation (n-6: n-3 fatty acids ratio: 1.79) and the comparison group receiving an olive oil preparation, for one month (2012/2013year). The studied dosage was 45ml (15ml 3 times per day). It was a randomized, double blinded study.

Results: The waist to hip ratio, GGTP levels, plasma platelet concentrations and flow mediated vasodilation of brachial artery (FMD) significantly improved in the experimental group. A significant decrease in daytime ABPM blood pressure was noticed in both groups.

Conclusions: A phospholipid-enriched diet caused a significant improvement of endothelial vasodilatory function and a significant decrease in waist to hip ratio. A significant decrease in daytime systolic blood pressure were observed in both the phospholipid-enriched and oil-olive group.

Keywords: Civilization diseases; Dietary pattern; Flow mediated dilatation; Nutrition; Olive oil.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chickens
  • Demography
  • Eggs*
  • Fatty Acids / analysis
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / drug therapy*
  • Middle Aged
  • Olive Oil / chemistry
  • Phospholipids / therapeutic use*


  • Fatty Acids
  • Olive Oil
  • Phospholipids