Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features

Head Neck Pathol. 2016 Mar;10(1):68-74. doi: 10.1007/s12105-016-0694-9. Epub 2016 Feb 1.


Adenocarcinomas of the sinonasal tract may originate from respiratory surface epithelium or the underlying seromucinous glands. These malignancies are divided into salivary-type adenocarcinomas and non-salivary-type adenocarcinomas. The latter are further divided into intestinal-type and nonintestinal-type adenocarcinomas. This review provides an update on tumor classification, differential diagnostic considerations and molecular features, as well as new adenocarcinoma entities in the sinonasal area.

Keywords: Immunohistochemistry; Intestinal-type adenocarcinoma; Molecular pathology; Nonintestinal-type adenocarcinoma; Salivary-type adenocarcinoma; Sinonasal adenocarcinoma; Wood dust exposure.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / classification*
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology*
  • Biomarkers, Tumor
  • Humans
  • Immunophenotyping
  • Paranasal Sinus Neoplasms / classification*
  • Paranasal Sinus Neoplasms / genetics
  • Paranasal Sinus Neoplasms / pathology*


  • Biomarkers, Tumor