Vasopressin-induced Ca(2+) signals in human adipose-derived stem cells

Cell Calcium. 2016 Mar;59(2-3):135-9. doi: 10.1016/j.ceca.2015.12.006. Epub 2016 Jan 6.


Intracellular Ca(2+) signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca(2+) concentration during adipogenesis via V1a receptors, Gq-proteins and the PLC-IP3 pathway in human adipose-derived stromal/stem cells (hASCs). These Ca(2+) signals originate through calcium release from pools within the endoplasmic reticulum and the extracellular space. AVP supplementation to the adipogenic media inhibits adipogenesis and key adipocyte marker genes. This review focuses on the intersection between AVP, Ca(2+) signals and ASC differentiation.

Keywords: Arginine vasopressin; Ca(2+) signaling; Differentiation; Human adipose-derived stem cells.

Publication types

  • Review

MeSH terms

  • Adipogenesis / drug effects
  • Adipose Tissue / cytology*
  • Adipose Tissue / drug effects*
  • Adipose Tissue / metabolism
  • Arginine Vasopressin / pharmacology*
  • Calcium / metabolism*
  • Calcium Signaling / drug effects*
  • Humans
  • Stem Cells / drug effects*
  • Stem Cells / metabolism*


  • Arginine Vasopressin
  • Calcium