Antioxidant activity of linalool in patients with carpal tunnel syndrome

BMC Neurol. 2016 Feb 2;16:17. doi: 10.1186/s12883-016-0541-3.


Background: Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS.

Methods: This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1% linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed.

Results: DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate.

Conclusions: Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclic Monoterpenes
  • Administration, Inhalation
  • Adult
  • Aged
  • Antioxidants / therapeutic use*
  • Blood Pressure / drug effects
  • Carpal Tunnel Syndrome / drug therapy*
  • Double-Blind Method
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Middle Aged
  • Monoterpenes / therapeutic use*


  • Acyclic Monoterpenes
  • Antioxidants
  • Monoterpenes
  • linalool