Genomic alterations in human breast cancer: a review

Tumori. 1989 Aug 31;75(4):311-20.


We review and discuss data on the genetic alterations documented in human breast carcinomas at the molecular level. These alterations may result in: 1) deletion of genetic material (chromosome 11p, 13q, 3p, 1q, 17p); 2) amplification of genes or entire chromosomal segments (c-myc, c-erb-B2, locus DF3/PUM, loci on 11q13); 3) rearrangements (c-myc); 4) point mutations (c-ras). Presently available informations do not allow the development of cohesive pathogenetic models but indicate that the molecular basis of human breast cancer is heterogeneous.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / genetics*
  • Chromosome Deletion
  • Female
  • Gene Amplification
  • Gene Rearrangement
  • Genes, ras
  • Humans
  • Mutation
  • Proto-Oncogenes
  • Transfection