Feeding the germline

Genes Dev. 2016 Feb 1;30(3):249-50. doi: 10.1101/gad.276980.115.


Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307-320) have used Caernohabditis elegans to identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.

Keywords: CRP; HT115; cytR; gld-1; nucleotide salvage pathway; nutrient sensing.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology*
  • Glucagon-Like Peptide 1 / metabolism*
  • Nucleotides / metabolism*
  • Receptors, Notch / metabolism*
  • Signal Transduction*


  • Nucleotides
  • Receptors, Notch
  • Glucagon-Like Peptide 1