Pancreatic Neuroendocrine Neoplasms

J N Rosenbaum; Ricardo Vincent Lloyd

doi:10.1016/j.path.2014.08.005

Pancreatic Neuroendocrine Neoplasms

Surg Pathol Clin. 2014 Dec;7(4):559-75. doi: 10.1016/j.path.2014.08.005. Epub 2014 Nov 8.

Authors

J N Rosenbaum¹, Ricardo Vincent Lloyd²

Affiliations

¹ Department of Surgical Pathology, University of Wisconsin Hospital and Clinics, Room A4/204-3224, 600 Highland Ave., Madison, WI 53792-3224, USA.
² Department of Surgical Pathology, University of Wisconsin Hospital and Clinics, Room A4/204-3224, 600 Highland Ave., Madison, WI 53792-3224, USA. Electronic address: rvlloyd@wisc.edu.

PMID: 26837555
DOI: 10.1016/j.path.2014.08.005

Abstract

Pancreatic neuroendocrine neoplasms (Pan-NENs) are rare but clinically important lesions. Pan-NENs are known for and often categorized by their capacity to produce clinical syndromes mediated by the production of hormones. Despite sometimes presenting dramatically from excessive hormone production, not all Pan-NENs produce functional hormone, and they can pose diagnostic challenges to practicing pathologists. Distinguishing Pan-NENs from mimics can be crucial, because Pan-NENs carry different prognoses and have unique treatments available due to their specific biological properties. This article reviews the current categorization and features of Pan-NENs.

Keywords: Cancer; Gastrinoma; Glucagonoma; Insulinoma; Ki-67; Neuroendocrine; Pan-NEN; Pancreas.

Publication types

Review