Abstract
Phytochemical investigation on the stems of C. tabularis (Meliaceae) led to the isolation of two new phragmalin-type limonoids, named tabularisins S and T (1-2), along with five known ones (3-7). The structures of the new limonoids were established by spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. All the compounds were evaluated for α-glucosidase inhibitory activity in vitro. Compounds 2 and 3 exhibited significant inhibitory activity against α-glucosidase with IC50 values of 0.15 and 0.03 mM, respectively (acarbose as positive control, IC50 0.95 mM).
Keywords:
Chukrasia tabularis; Meliaceae; limonoid; α-glucosidase activity.
MeSH terms
-
Drugs, Chinese Herbal* / chemistry
-
Drugs, Chinese Herbal* / isolation & purification
-
Drugs, Chinese Herbal* / pharmacology
-
Glycoside Hydrolase Inhibitors* / chemistry
-
Glycoside Hydrolase Inhibitors* / isolation & purification
-
Glycoside Hydrolase Inhibitors* / pharmacology
-
Limonins* / chemistry
-
Limonins* / isolation & purification
-
Limonins* / pharmacology
-
Meliaceae / chemistry*
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Bark / chemistry
-
Plant Stems / chemistry
-
alpha-Glucosidases / drug effects*
Substances
-
Drugs, Chinese Herbal
-
Glycoside Hydrolase Inhibitors
-
Limonins
-
phragmalin
-
tabularisin S
-
tabularisin T
-
alpha-Glucosidases