Novel Insights Into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation: Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme

Circ Res. 2016 Jan 22;118(2):196-8. doi: 10.1161/CIRCRESAHA.115.307875.

Authors

Massimo Volpe¹, Speranza Rubattu¹

Affiliation

¹ From the Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome; and IRCCS Neuromed, Angio-Cardio-Neurology Department, Pozzilli, Italy.

PMID: 26838312
DOI: 10.1161/CIRCRESAHA.115.307875

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atrial Natriuretic Factor / metabolism*
Blood Pressure*
Cell Line
Enzyme Activation
Humans
Hypertension / enzymology*
Hypertension / genetics
Hypertension / physiopathology
Mice
Mice, Knockout
Myocardium / enzymology*
Proprotein Convertases / deficiency
Proprotein Convertases / genetics
Proprotein Convertases / metabolism*
Protein Precursors / metabolism*
Serine Endopeptidases / genetics
Serine Endopeptidases / metabolism*
Signal Transduction
Transfection

Substances

Protein Precursors
Atrial Natriuretic Factor
CORIN protein, human
Corin protein, mouse
PCSK6 protein, human
Pcsk6 protein, mouse
Proprotein Convertases
Serine Endopeptidases