Synthesis and characterization of a HAp-based biomarker with controlled drug release for breast cancer

Mater Sci Eng C Mater Biol Appl. 2016 Apr 1:61:801-8. doi: 10.1016/j.msec.2016.01.015. Epub 2016 Jan 7.


A biocompatible hybrid porous polymer-ceramic material was synthesized to be used as a biomarker in the treatment of breast cancer. This device was equipped with the capacity to release medicaments locally in a controlled manner. The biomaterial was Hydroxyapatite(HAp)-based and had a controlled pore size and pore volume fraction. It was implemented externally using a sharp end and a pair of barbed rings placed opposite each other to prevent relative movement once implanted. The biomarker was impregnated with cis-diamine dichloride platinum (II) [Cl2-Pt-(NH3)2]; the rate of release was obtained using inductively coupled plasma atomic emission spectroscopy (ICP-AES), and release occurred over the course of three months. Different release profiles were obtained as a function of the pore volume fraction. The biomaterial was characterized using scanning electron microscopy (SEM) and Raman spectroscopy.

Keywords: Biomarkers; Breast cancer; Cisplatin; Drug controlled release; Implant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Biomarkers, Tumor / analysis
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Ceramics / chemistry
  • Cisplatin / administration & dosage
  • Cisplatin / chemistry
  • Cisplatin / metabolism*
  • Drug Carriers / chemical synthesis*
  • Drug Carriers / chemistry
  • Drug Liberation
  • Durapatite / chemistry*
  • Female
  • Humans
  • Microscopy, Electron, Scanning
  • Polymers / chemistry
  • Porosity
  • Spectrum Analysis, Raman


  • Biocompatible Materials
  • Biomarkers, Tumor
  • Drug Carriers
  • Polymers
  • Durapatite
  • Cisplatin