Spatial structure of neuronal receptive field in awake monkey secondary visual cortex (V2)

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1913-8. doi: 10.1073/pnas.1525505113. Epub 2016 Feb 2.


Visual processing depends critically on the receptive field (RF) properties of visual neurons. However, comprehensive characterization of RFs beyond the primary visual cortex (V1) remains a challenge. Here we report fine RF structures in secondary visual cortex (V2) of awake macaque monkeys, identified through a projection pursuit regression analysis of neuronal responses to natural images. We found that V2 RFs could be broadly classified as V1-like (typical Gabor-shaped subunits), ultralong (subunits with high aspect ratios), or complex-shaped (subunits with multiple oriented components). Furthermore, single-unit recordings from functional domains identified by intrinsic optical imaging showed that neurons with ultralong RFs were primarily localized within pale stripes, whereas neurons with complex-shaped RFs were more concentrated in thin stripes. Thus, by combining single-unit recording with optical imaging and a computational approach, we identified RF subunits underlying spatial feature selectivity of V2 neurons and demonstrated the functional organization of these RF properties.

Keywords: V2; natural images; receptive field; stripes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Macaca / physiology*
  • Models, Biological
  • Neurons / physiology*
  • Visual Cortex / cytology
  • Visual Cortex / physiology*
  • Wakefulness*