Replication Origins: Determinants or Consequences of Nuclear Organization?

Curr Opin Genet Dev. 2016 Apr;37:67-75. doi: 10.1016/j.gde.2015.11.008. Epub 2016 Feb 2.

Abstract

Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability. The distribution of replication initiation events is responsive to local and global changes in chromatin structure and is affected by transcriptional activity. Concomitantly, replication origin sequences, which determine the locations of replication initiation events, can affect chromatin structure and modulate transcriptional efficiency. The flexibility observed in the replication initiation landscape might help achieve complete and accurate genome duplication while coordinating the DNA replication program with transcription and other nuclear processes in a cell-type specific manner. This review discusses the relationships among replication origin distribution, local and global chromatin structures and concomitant nuclear metabolic processes.

Publication types

  • Review
  • Research Support, N.I.H., Intramural

MeSH terms

  • Chromatin / genetics*
  • Chromatin Assembly and Disassembly / genetics*
  • DNA Replication / genetics
  • Genomic Instability*
  • Humans
  • Replication Origin / genetics*

Substances

  • Chromatin