Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses

ACS Chem Biol. 2016 Mar 18;11(3):669-80. doi: 10.1021/acschembio.5b00999. Epub 2016 Feb 15.


Persistent viral infections are widespread and represent significant public health burdens. Some viruses endure in a latent state by co-opting the host epigenetic machinery to manipulate viral gene expression. Small molecules targeting epigenetic pathways are now in the clinic for certain cancers and are considered as potential treatment strategies to reverse latency in HIV-infected individuals. In this review, we discuss how drugs interfering with one epigenetic pathway, protein acetylation, perturb latency of three families of pathogenic human viruses-retroviruses, herpesviruses, and papillomaviruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Drug Delivery Systems
  • Epigenesis, Genetic
  • Gene Expression Regulation / drug effects*
  • Humans
  • Virus Latency / physiology*


  • Antiviral Agents