Circ Res. 2016 Feb 5;118(3):496-514. doi: 10.1161/CIRCRESAHA.115.306573.


Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention.

Keywords: cardiovascular infections; communicable diseases; heart diseases; myocarditis; virus diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biopsy
  • Diagnostic Imaging / methods
  • Electrocardiography
  • Heart / physiopathology
  • Heart / virology*
  • Host-Pathogen Interactions
  • Humans
  • Myocarditis / diagnosis
  • Myocarditis / epidemiology
  • Myocarditis / physiopathology
  • Myocarditis / therapy
  • Myocarditis / virology*
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Viruses / pathogenicity*