Postural Orthostatic Tachycardia Syndrome (POTS)--A novel member of the autoimmune family

Lupus. 2016 Apr;25(4):339-42. doi: 10.1177/0961203316629558. Epub 2016 Feb 3.


Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system in which a change from the supine position to an upright position causes an abnormally large increase in heart rate or tachycardia (30 bpm within 10 min of standing or head-up tilt). This response is accompanied by a decrease in blood flow to the brain and hence a spectrum of symptoms associated with cerebral hypoperfusion. Many of these POTS-related symptoms are also observed in chronic anxiety and panic disorders, and therefore POTS is frequently under- and misdiagnosed.

Keywords: Postural orthostatic tachycardia syndrome (POTS); autoantibodies; autoimmunity; chronic fatigue syndrome (CFS); human papilloma virus (HPV); molecular mimicry.

Publication types

  • Editorial

MeSH terms

  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / epidemiology
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / physiopathology
  • Autoimmunity*
  • Capsid Proteins / immunology
  • Cerebrovascular Circulation
  • Cross Reactions
  • Death, Sudden, Cardiac / epidemiology
  • Heart Rate
  • Humans
  • Oncogene Proteins, Viral / immunology
  • Papillomavirus Vaccines / immunology
  • Postural Orthostatic Tachycardia Syndrome / diagnosis
  • Postural Orthostatic Tachycardia Syndrome / epidemiology
  • Postural Orthostatic Tachycardia Syndrome / immunology*
  • Postural Orthostatic Tachycardia Syndrome / physiopathology
  • Risk Factors
  • Supine Position


  • Capsid Proteins
  • Oncogene Proteins, Viral
  • Papillomavirus Vaccines
  • L1 protein, Human papillomavirus type 16