The emerging role of myeloid-derived suppressor cells in lung diseases

Eur Respir J. 2016 Mar;47(3):967-77. doi: 10.1183/13993003.01572-2015. Epub 2016 Feb 4.


Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterised by their potential to control T-cell responses and to dampen inflammation. While the role of MDSCs in cancer has been studied in depth, our understanding of their relevance for infectious and inflammatory disease conditions has just begun to evolve. Recent studies highlight an emerging and complex role for MDSCs in pulmonary diseases. In this review, we discuss the potential contribution of MDSCs as biomarkers and therapeutic targets in lung diseases, particularly lung cancer, tuberculosis, chronic obstructive pulmonary disease, asthma and cystic fibrosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Asthma / immunology
  • Cystic Fibrosis / immunology
  • Humans
  • Lung Diseases / immunology*
  • Lung Neoplasms / immunology
  • Myeloid-Derived Suppressor Cells / immunology*
  • Pulmonary Disease, Chronic Obstructive / immunology
  • T-Lymphocytes / immunology*
  • Tuberculosis / immunology