Time to Relax: Mechanical Stress Release Guides Stem Cell Responses

Cell Stem Cell. 2016 Feb 4;18(2):166-7. doi: 10.1016/j.stem.2016.01.020.


Stem cells integrate spatiotemporal cues, including the mechanical properties of their microenvironment, into their fate decisions. Chaudhuri et al. (2015) show that the ability of the extracellular matrix to dissipate cell-induced forces, referred to as stress-relaxation, is a key mechanical signal influencing stem cell fate and function.

Publication types

  • Comment

MeSH terms

  • Humans
  • Mesenchymal Stem Cells / physiology*