Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Cent Eur J Public Health. 2015 Nov:23 Suppl:S19-22. doi: 10.21101/cejph.a4105.

Abstract

Aim: The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G>A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females.

Methods: We genotyped 139 unrelated non-diabetic Czech females (49.5 ± 13.3 years, average BMI at baseline 32.2 ± 4.6 kg/m². Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention.

Conclusion: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.

Keywords: NYD-SP18; females; intervention; obesity; polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Body Composition / genetics*
  • Czech Republic
  • Diet, Reducing
  • Exercise
  • Female
  • GTPase-Activating Proteins / genetics*
  • Genotype
  • Humans
  • Life Style
  • Middle Aged
  • Obesity / genetics*
  • Obesity / prevention & control
  • Overweight / genetics*
  • Overweight / prevention & control
  • Polymorphism, Single Nucleotide / genetics*
  • Weight Loss / genetics*

Substances

  • FAM13A protein, human
  • GTPase-Activating Proteins