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. 2015 Nov;23 Suppl:S19-22.
doi: 10.21101/cejph.a4105.

Body Composition Changes in Adult Females After Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

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Body Composition Changes in Adult Females After Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Pavel Suchánek et al. Cent Eur J Public Health. .
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Abstract

Aim: The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G>A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females.

Methods: We genotyped 139 unrelated non-diabetic Czech females (49.5 ± 13.3 years, average BMI at baseline 32.2 ± 4.6 kg/m². Biochemical and anthropometrical measurements were performed before and after ten weeks of lifestyle intervention.

Conclusion: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.

Keywords: NYD-SP18; females; intervention; obesity; polymorphism.

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