[Epigenetics in transgenerational responses to environmental impacts: from facts and gaps]

Med Sci (Paris). 2016 Jan;32(1):35-44. doi: 10.1051/medsci/20163201007. Epub 2016 Feb 5.
[Article in French]


The existence of non-genetic and non-cultural mechanisms that transfer information on the memory of parental exposures to various environments, determining the reactivity of the following generations to their environments during their life, are of growing interest. Yet fundamental questions remain about the nature, the roles and relative importance of epigenetic marks and processes, non-coding RNAs, or other mechanisms, and their persistence over generations. A model incorporating the various transmission systems, their cross-talks and windows of susceptibility to the environment as a function of sex/gender of parent and offspring, has yet to be built.

Publication types

  • Review

MeSH terms

  • DNA Methylation / physiology
  • Disease Susceptibility / etiology
  • Environment*
  • Epigenesis, Genetic / physiology*
  • Family Characteristics
  • Female
  • Gene-Environment Interaction
  • Humans
  • Pregnancy
  • Prenatal Exposure Delayed Effects / etiology*
  • Prenatal Exposure Delayed Effects / genetics
  • RNA, Untranslated / physiology


  • RNA, Untranslated