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Review
. 2016 Jan;32(1):45-50.
doi: 10.1051/medsci/20163201008. Epub 2016 Feb 5.

[Developmental and Environnemental Origin of Male Infertility: Role of Endocrine Disruptors]

[Article in French]
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Free article
Review

[Developmental and Environnemental Origin of Male Infertility: Role of Endocrine Disruptors]

[Article in French]
Claire Mauduit et al. Med Sci (Paris). .
Free article

Abstract

Human and wildlife exposure to chemicals is thought to be extensive and particularly to endocrine-disrupting chemicals (EDCs) suspected to alter male reproductive tract. When the exposure occurs during perinatal period (fetal, neonatal periods or puberty) the reproductive health alterations are irreversible suggesting a developmental origin to male infertility. This concept is supported by numerous epidemiologic and experimental studies. This review summarizes the data concerning the epigenetic mechanisms (DNA methylation, chromatin remodelling, small-non coding RNAs) involved in developmentally-induced male infertility. These data open potentially to new diagnosis tools and new trails to assessment of EDCs risks.

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