[Developmental and environnemental origin of male infertility: role of endocrine disruptors]

Med Sci (Paris). 2016 Jan;32(1):45-50. doi: 10.1051/medsci/20163201008. Epub 2016 Feb 5.
[Article in French]


Human and wildlife exposure to chemicals is thought to be extensive and particularly to endocrine-disrupting chemicals (EDCs) suspected to alter male reproductive tract. When the exposure occurs during perinatal period (fetal, neonatal periods or puberty) the reproductive health alterations are irreversible suggesting a developmental origin to male infertility. This concept is supported by numerous epidemiologic and experimental studies. This review summarizes the data concerning the epigenetic mechanisms (DNA methylation, chromatin remodelling, small-non coding RNAs) involved in developmentally-induced male infertility. These data open potentially to new diagnosis tools and new trails to assessment of EDCs risks.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Animals, Wild
  • Endocrine Disruptors / pharmacology
  • Endocrine Disruptors / toxicity*
  • Environmental Exposure / adverse effects*
  • Environmental Pollutants / toxicity*
  • Female
  • Humans
  • Infant, Newborn
  • Infertility, Male / chemically induced
  • Infertility, Male / etiology*
  • Male
  • Pregnancy
  • Prenatal Exposure Delayed Effects* / chemically induced
  • Prenatal Exposure Delayed Effects* / physiopathology


  • Endocrine Disruptors
  • Environmental Pollutants