Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial

Complement Ther Clin Pract. 2016 Feb;22:44-50. doi: 10.1016/j.ctcp.2015.12.003. Epub 2015 Dec 12.


The study was designed to determine the effect of thirty days of pomegranate extract oral supplementation on plasma inflammatory and oxidative stress biomarkers as well as serum metabolic profiles, in overweight and obese individuals. In this randomized, double-blind, placebo-controlled study 48 obese and overweight participants were randomly assigned to receive either 1000 mg of pomegranate extract, or a placebo, daily for 30 days. At baseline, and after 30 days of treatment, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, interleukin-6 and hyper sensitive-C reactive protein and levels of serum lipids, glucose and insulin were assessed. Thirty days of PE supplementation resulted in a significant decrease in mean serum levels of glucose, insulin, total cholesterol, LDL-C, and plasma MDA, IL-6 and hs-CRP. HDL-C significantly increased following the PE versus the PL intervention. Our study suggests that pomegranate extract consumption may reduce complications linked with obesity.

Keywords: Inflammation; Lipid peroxidation; Obesity; Polyphenols; Pomegranate extract.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Antioxidants / analysis
  • Diet
  • Dietary Supplements
  • Humans
  • Inflammation / complications
  • Inflammation / drug therapy*
  • Lythraceae*
  • Middle Aged
  • Obesity / complications*
  • Overweight / complications*
  • Phytotherapy
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use*


  • Antioxidants
  • Plant Extracts