Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology

Cancer Discov. 2016 Feb;6(2):125-7. doi: 10.1158/2159-8290.CD-15-1470.


A majority of adenoid cystic carcinomas (AdCC)-rare tumors of the salivary gland and some other organs-have recently been found to be driven by chromosomal translocations resulting in MYB-NFIB fusions. Brayer and colleagues and Mitani and colleagues have now reported that AdCCs can alternatively be driven by similar rearrangements involving a second MYB family gene, MYBL1, and that these two drivers act in remarkably similar ways.

Publication types

  • Comment

MeSH terms

  • Carcinoma, Adenoid Cystic*
  • Genes, myb
  • Humans
  • Oncogene Proteins, Fusion / genetics*
  • Translocation, Genetic


  • Oncogene Proteins, Fusion